Wednesday, May 9, 2018
REGISTRATION & CONTINENTAL BREAKFAST
7:00 - 8:00  
WELCOME
8:00 - 8:15

Welcome and Introduction to the Programme

Harley Eisman, MD, Co-Founder, Hereditary Breast and Ovarian Cancer Foundation, Montréal, QC, Canada


William Foulkes, MBBS, PhD, Director, Program in Cancer Genetics, McGill University, Montréal, QC, Canada


Overview of Today’s Sessions

William Foulkes, MBBS, PhD, Director, Program in Cancer Genetics, McGill University, Montréal, QC, Canada

SESSION 1:
BRCA biology and gene variants
8:15 - 9:45

CHAIR: Lawrence Brody, PhD, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA

8:15 - 8:35

BIC, ENIGMA, BRCA Exchange and ClinVar: Where are we with data integration?

Amanda Spurdle, PhD, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

8:35 - 8:55

BRCA1/2 VUS: What’s new in variant classification?

Alvaro Monteiro, PhD, Moffitt Cancer Center, Tampa, FL, USA

Proffered paper 1

Proffered paper 2

Proffered paper 3

9:25 - 9:45

Question and discussion period (all speakers)

BREAK
9:45 - 10:15  
SESSION 2:
Molecular genetics and pathology of inherited forms of breast and gynecological cancers
10:15 - 11:45

CHAIR: Jorge Reis-Filho, MD, PhD, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

10:15 - 10:35

Breast cancer pathology, treatment and outcome in ATM, BRCA1, BRCA2, CHEK2 and PALB2 mutation carriers

Marjanka Schmidt, PhD, Netherlands Cancer Institute, Amsterdam, The Netherlands

10:35 - 10:55

Classifying ovarian cancers using molecular genetics and histology

Blaise Clarke, MD, University Health Network, Toronto, ON, Canada

Proffered paper 1

Proffered paper 2

Proffered paper 3

11:25 - 11:45

Question and discussion period (all speakers)

LUNCH

11:45 - 13:15  

SESSION 3:
DNA Repair in the clinic: origins, diagnosis and outcomes
13:15 - 14:45

CHAIR: Laura van’t Veer, PhD, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA

13:15 - 13:35

Genomic Consequences of Aberrant DNA repair in Breast and Ovarian cancer – implications for therapy

Sohrab Shah, PhD, Canada Research Chair in Computational Cancer Genomics, University of British Columbia and BC Cancer Agency, Vancouver, BC, Canada

13:35 - 13:55

DNA Repair in Clinical Practice

Daniel Silver, MD, PhD, Thomas Jefferson University, Philadelphia, PA, USA

Proffered paper 1

Proffered paper 2

Proffered paper 3

14:25 - 14:45

Question and discussion period (all speakers)

POSTER SESSION 1
    (with break)
14:45 - 16:30
SESSION 4:
Special Round Table: BRCA1/2 clinical practice – global perspectives
16:30 - 18:00

MODERATORS: Mark Robson, MD, Memorial Sloan-Kettering Cancer Center, New York, NY, USA ; and Lawrence Brody, PhD, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA

South America:

Maria Isabel Achatz, MD, PhD, National Cancer Institute, Rockville, MD, USA

Europe:

Dominique Stoppa-Lyonnet, PhD, Institut Curie, Paris, France

Two other speakers:

(Asia and Africa - TBC)